Five Platform Technologies

Isolation and purification of xenograft derived type I collagen fibers:

• Involves sequential extraction of non-collagenous materials from the tissues
• Purified type I collagen fibers are disintegrated and reconstituted to collagen fibers that can be engineered into a variety of shapes and forms with controllable properties such as pore structure, density, strength, dimension and resorption time

Intact Collagen Fiber Matrix technology involves the purification and processing of intact xenograft tissue:

• Intact xenograft tissue (e.g., dermis, pericardium, peritoneum) is purified and processed to manufacture intact collagen fiber matrices for medical and dental applications

Natural Carbonate Apatite and Synthetic Carbonate Apatite

• Natural carbonate apatite is derived from animal bone and manufactured by Collagen Matrix
• Synthetic carbonate apatite is manufactured by a contract manufacturer for Collagen Matrix

Proprietary natural anorganic bone mineral process in which the cancellous and cortical bone is deproteinated to remove organic components.

Resulting calcium phosphate particulate is used in bone grafting applications.

Collagen Matrix has developed proprietary methods for coating devices with type I collagen based materials. A thin layer of uniform collagen based material can be coated and stabilized onto metal and polymer based devices of any geometry and surface morphology, including those devices with irregular geometries and/or small holes and crevasses. Collagen based surface coating enhances osteointegration. The coating technology can be applied to stents, dental implants, coils and other implants. Drugs and/or other bioactive agents can be incorporated for elution at specific anatomic sites in the body.

The key advantage of a fully resorbable drug-eluting coating, for example, in stents, is that the coating only stays in vivo long enough to elute the drug in a desired period of time, eliminating any concern of long-term effects of exposure to coating components in the blood stream. In addition to selected drugs, Collagen Matrix’s coating can incorporate heparin to improve the hemocompatibility of the device while the coating is maintained. The coating does not alter the method of delivery or mechanical function of the device.

Coating with type I collagen based material can:

• Enhance the biological activity and biocompatibility of a device
• Increase osteointegration
• Improve the blood compatibility of a device
• Elute drugs or other bioactive agents with therapeutic indications
• Eliminate concerns of long-term exposure to the coating materials as it is resorbable with a controlled resorption time